Document Detail

Regulation of breathing in hyperthyroidism: relationship to hormonal and metabolic changes.
MedLine Citation:
PMID:  9727792     Owner:  NLM     Status:  MEDLINE    
We sought to examine the breathing pattern, inspiratory drive and chemosensitivity of hyperthyroid patients and to explore the interactions between their thyroid hormones, basal metabolism and chemosensitivity. We studied 15 hyperthyroid patients and 15 sex- and age-matched controls. Thyroid hormone levels, arterial blood gas tensions, lung volumes, diffusing capacity for CO, maximal respiratory pressures and oxygen uptake measurements were performed. Breathing pattern and mouth occlusion pressure (P0.1), as well as ventilatory and P0.1 responses to hyperoxic progressive hypercapnia and isocapnic progressive hypoxia, were also evaluated. Compared with the control subjects, the hyperthyroid patients showed significantly lower resting arterial CO2 tension, tidal volume and significantly higher mean inspiratory flow and P0.1. Ventilatory and P0.1 responses to CO2 and hypoxia were also greater in the hyperthyroid patients than in the control group. All these changes returned to normal after treatment. In the patients, significant relationships between tri-iodothyronine and P0.1, P0.1 response to hypoxia, and P0.1 response to hypercapnia were found. In contrast, in hyperthyroidism there was no relationship between oxygen uptake and P0.1 response to hypoxia. We conclude that hyperthyroid patients exhibit a significant relationship between their thyroid hormone levels and their increased inspiratory drive and chemosensitivity.
J M Pino-García; F García-Río; J J Díez; M A Gómez-Mendieta; M A Racionero; S Díaz-Lobato; J Villamor
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  12     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-20     Completed Date:  1998-11-20     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  400-7     Citation Subset:  IM    
Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain.
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MeSH Terms
Blood Gas Analysis
Case-Control Studies
Chemoreceptor Cells / physiopathology*
Goiter, Nodular / drug therapy,  physiopathology*
Graves Disease / drug therapy,  physiopathology*
Oxygen Consumption
Respiratory Function Tests
Thyroid Hormones / metabolism*
Reg. No./Substance:
0/Thyroid Hormones

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