| Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 18541149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The branched-chain alpha-keto acid dehydrogenase (BCKDH) complex is the most important regulatory enzyme in branched-chain amino acid (BCAA) catabolism. We examined the regulation of hepatic BCKDH complex activity in spontaneous type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Zucker diabetic fatty rats. Hepatic BCKDH complex activity in these rats was significantly lower than in corresponding control rats. The amount of BCKDH complex in OLETF rats corresponded to the total activity of the complex. Activity and abundance of the bound form of BCKDH kinase, which is responsible for inactivation of the complex, showed an inverse correlation to BCKDH complex activity in OLETF rats. Dietary supplementation of 5% BCAAs for 10 weeks markedly increased BCKDH complex activity, and decreased the activity and bound form of BCKDH kinase in the rats. These results suggest that BCAA catabolism in type 2 diabetes is downregulated and enhanced by BCAA supplementation. |
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Authors:
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Teiji Kuzuya; Yoshiaki Katano; Isao Nakano; Yoshiki Hirooka; Akihiro Itoh; Masatoshi Ishigami; Kazuhiko Hayashi; Takashi Honda; Hidemi Goto; Yuko Fujita; Rie Shikano; Yuji Muramatsu; Gustavo Bajotto; Tomohiro Tamura; Noriko Tamura; Yoshiharu Shimomura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-09 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 373 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-01 Completed Date: 2008-07-31 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 94-8 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
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metabolism* Amino Acids, Branched-Chain / administration & dosage, blood, metabolism* Animals Citrate (si)-Synthase / metabolism Diabetes Mellitus, Type 2 / enzymology, metabolism* Diet Disease Models, Animal Down-Regulation Liver / enzymology* Protein Kinases / metabolism* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain; EC 1.2.4.4/3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); EC 2.3.3.1/Citrate (si)-Synthase; EC 2.7.-/Protein Kinases; EC 2.7.1.-/BCKAD kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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