| Regulation of body fluid and salt homeostasis--from observations in space to new concepts on Earth. | |
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MedLine Citation:
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PMID: 16101468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present manuscript summarizes recent discoveries that were made by studying salt and fluid homeostasis in weightlessness. These data indicate that 1. atrial natriuretic peptide appears not to play an important role in natriuresis in physiology, 2. the distribution of body fluids appears to be tightly coupled with hunger and thirst regulation, 3. intrathoracic pressure may be an important co-regulator of body fluid homeostasis, 4. a so far unknown low-affinity, high capacity osmotically inactive sodium storage mechanism appears to be present in humans that is acting through sodium/hydrogen exchange on glycosaminoglycans and might explain the pathophysiology, e.g., of salt sensitive hypertension. The surprising and unexpected data underline that weightlessness is an excellent tool to investigate the physiology of our human body: If we knew it, we should be able to predict changes that occur when gravity is absent. But, as data from space demonstrate, we do not. |
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Authors:
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R Gerzer; M Heer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current pharmaceutical biotechnology Volume: 6 ISSN: 1389-2010 ISO Abbreviation: Curr Pharm Biotechnol Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-16 Completed Date: 2006-04-12 Revised Date: 2008-05-12 |
Medline Journal Info:
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Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 299-304 Citation Subset: IM |
Affiliation:
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Institute of Aerospace Medicine, German Aerospace Centre DLR, 51147 Cologne, Germany. Rupert.gerzer@dlr.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Fluids
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physiology* Dizziness Earth (Planet) Humans Sodium / physiology* Space Flight* Water-Electrolyte Balance / physiology* Weightlessness |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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