Document Detail


Regulation of blood pressure with calcium-dependent dopamine synthesizing system in the brain and its related phenomena.
MedLine Citation:
PMID:  9370048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of calcium on blood pressure regulation remain controversial. Although the mechanism by which calcium increases blood pressure when it is given intravenously and acutely has been elucidated, that by which calcium reduces blood pressure when it is supplemented chronically and slightly through daily diet is unclear. From a number of animal experiments concerning the effects of calcium on blood pressure, we believe that calcium ions have two separate roles in the regulation of blood pressure through both central and peripheral systems: (1) calcium ions reduce blood pressure through a central, calcium/calmodulin-dependent dopamine-synthesizing system and (2) calcium ions increase blood pressure through an intracellular, calcium-dependent mechanism in the peripheral vasculature. These concepts were applied to elucidate the mechanisms underlying hypertension in spontaneously hypertensive rats (SHR) and changes in blood pressure in other experimental animals, and the following conclusions were reached. The decrease of the serum calcium level in spontaneously hypertensive rats (SHR) causes a decrease in calcium/calmodulin-dependent dopamine synthesis in the brain. The subsequent low level of brain dopamine induces hypertension. The increase in susceptibility to epileptic convulsions and the occurrence of hypertension in epileptic mice (El mice) may be linked through a lowering of calcium-dependent dopamine synthesis in the brain, and epilepsy and hypertension may be associated. Exercise leads to increases in calcium-dependent dopamine synthesis in the brain, and the increased dopamine levels induce physiological changes, including a decrease in blood pressure. Cadmium which is not distinguished from calcium by calmodulin, activates calmodulin-dependent functions in the brain, and increased dopamine levels may decrease blood pressure. In this report, our studies are considered in light of reports from many other laboratories.
Authors:
D Sutoo; K Akiyama
Related Documents :
19893088 - Effects of angiotensin ii type-1 receptor blocker losartan on age-related cardiovascula...
434168 - Role of receptor elements in baroceptor resetting.
8476428 - A neuropeptide y locus on chromosome 4 cosegregates with blood pressure in the spontane...
20667508 - Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spon...
9374078 - Arterial to end-tidal carbon dioxide gradient and physiological dead space monitoring d...
12034058 - Long-term thyroxine administration protects the heart in a pattern similar to ischemic ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Brain research. Brain research reviews     Volume:  25     ISSN:  -     ISO Abbreviation:  Brain Res. Brain Res. Rev.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-09     Completed Date:  1998-01-09     Revised Date:  2007-02-26    
Medline Journal Info:
Nlm Unique ID:  8908638     Medline TA:  Brain Res Brain Res Rev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-26     Citation Subset:  IM    
Affiliation:
Institute of Medical Science, University of Tsukuba, Japan. dustoo@md.tsukuba.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects,  physiology*
Brain / drug effects,  physiology*
Cadmium / pharmacology
Calcium / pharmacology*,  physiology*
Calmodulin / physiology
Dopamine / biosynthesis*
Exercise / physiology
Homeostasis
Humans
Hypertension / physiopathology*
Mice
Rats
Rats, Inbred SHR
Chemical
Reg. No./Substance:
0/Calmodulin; 7440-43-9/Cadmium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical erythrokinetics: a critical review.
Next Document:  Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug tran...