Document Detail


Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids.
MedLine Citation:
PMID:  6269406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stimulation of the beta-adrenergic receptor increases the enzymatic methylation of membrane phospholipids. Increased synthesis of phosphatidyl-N-monomethylethanolamine by methyltransferase I increases fluidity and enhances the ability of the beta-adrenergic receptor to couple with adenylate cyclase. The number of beta-adrenergic receptors can be regulated by the rate of synthesis and of degradation of phosphatidylcholine formed by transmethylation.
Authors:
W J Strittmatter; F Hirata; J Axelrod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in cyclic nucleotide research     Volume:  14     ISSN:  0084-5930     ISO Abbreviation:  Adv Cyclic Nucleotide Res     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0341362     Medline TA:  Adv Cyclic Nucleotide Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism
Erythrocyte Membrane / metabolism
Isoproterenol / pharmacology
Lipid Bilayers
Membrane Fluidity
Membrane Lipids / physiology*
Methylation
Methyltransferases / metabolism*
Phospholipids / physiology*
Receptors, Adrenergic / metabolism*
Receptors, Adrenergic, beta / metabolism*
Reticulocytes / metabolism
Chemical
Reg. No./Substance:
0/Lipid Bilayers; 0/Membrane Lipids; 0/Phospholipids; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 7683-59-2/Isoproterenol; EC 2.1.1.-/Methyltransferases

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