Document Detail

Regulation of base balance in bicarbonate hemofiltration.
MedLine Citation:
PMID:  8188396     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the feasibility of bicarbonate as a substitute for acetate or lactate in hemofiltration solutions using a new bag for the bicarbonate substitution fluid. We analysed 24 hemofiltration sessions with different HCO3- concentrations (30, 35 and 40 mEq/L) in the substitution fluid. The increase in the HCO3- concentration in the substitution fluid resulted in a more positive HCO3- balance. The Net Base Gains (NBG) were, respectively, 73.7 +/- 92 with 30, 138.2 +/- 97 with 35 (p < 0.05 vs 30) and finally 201 +/- 65.9 with 40 mEq/L (p < 0.001 vs 30). The physical separation between the base losses and gains could facilitate the modelling approach in hemofiltration. By means of a stepwise regression analysis, we studied a series of variables that could influence end-treatment HCO3-, which was significantly and directly dependent (F = 6.003, r = 0.747, p = 0.0027) on the HCO3- concentration in the substitution fluid and the apparent HCO3- space. HCO3- values predicted by the statistical model correlated well with those actually measured (r = 0.757; p < 0.001). This mathematical modelling approach allowed us to predict the quantities and concentrations of HCO3- to be infused in order to obtain an ideal acidosis correction, tailored to individual patient needs.
A Santoro; G Ferrari; R Bolzani; M Spongano; P Zucchelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  17     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-06-21     Completed Date:  1994-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  IM    
Department of Nephrology and Dialysis, S. Orsola-Malpighi Hospital, Bologna, Italy.
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MeSH Terms
Acid-Base Equilibrium*
Kidney Failure, Chronic / metabolism,  therapy
Middle Aged
Models, Biological
Reg. No./Substance:
0/Bicarbonates; 0/Solutions
Comment In:
Int J Artif Organs. 1994 Oct;17(10):565-6   [PMID:  7741927 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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