| Regulation of base balance in bicarbonate hemofiltration. | |
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MedLine Citation:
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PMID: 8188396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the feasibility of bicarbonate as a substitute for acetate or lactate in hemofiltration solutions using a new bag for the bicarbonate substitution fluid. We analysed 24 hemofiltration sessions with different HCO3- concentrations (30, 35 and 40 mEq/L) in the substitution fluid. The increase in the HCO3- concentration in the substitution fluid resulted in a more positive HCO3- balance. The Net Base Gains (NBG) were, respectively, 73.7 +/- 92 with 30, 138.2 +/- 97 with 35 (p < 0.05 vs 30) and finally 201 +/- 65.9 with 40 mEq/L (p < 0.001 vs 30). The physical separation between the base losses and gains could facilitate the modelling approach in hemofiltration. By means of a stepwise regression analysis, we studied a series of variables that could influence end-treatment HCO3-, which was significantly and directly dependent (F = 6.003, r = 0.747, p = 0.0027) on the HCO3- concentration in the substitution fluid and the apparent HCO3- space. HCO3- values predicted by the statistical model correlated well with those actually measured (r = 0.757; p < 0.001). This mathematical modelling approach allowed us to predict the quantities and concentrations of HCO3- to be infused in order to obtain an ideal acidosis correction, tailored to individual patient needs. |
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Authors:
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A Santoro; G Ferrari; R Bolzani; M Spongano; P Zucchelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of artificial organs Volume: 17 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-06-21 Completed Date: 1994-06-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: ITALY |
Other Details:
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Languages: eng Pagination: 27-36 Citation Subset: IM |
Affiliation:
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Department of Nephrology and Dialysis, S. Orsola-Malpighi Hospital, Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium* Adult Aged Bicarbonates Female Hemofiltration* Humans Kidney Failure, Chronic / metabolism, therapy Male Middle Aged Models, Biological Solutions |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Solutions |
| Comments/Corrections | |
Comment In:
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Int J Artif Organs. 1994 Oct;17(10):565-6
[PMID:
7741927
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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