Document Detail

Regulation of the bacterial microflora of the vagina in cyclic female rats.
MedLine Citation:
PMID:  21936     Owner:  NLM     Status:  MEDLINE    
The bacterial microflora was examined in the vagina of cyclic female rats kept under normal laboratory conditions. Large variations occurred during the cycle with high numbers of bacteria (10(5)-10(8) per vagina) during proestrus and estrus and low numbers (10(1)-10(4) per vagina) during the diestrus period. Histological analysis of in situ vaginal tissue and transplanted vaginal tissue revealed an association of high bacterial numbers with the presence of large amounts of cellular debris in the vaginal lumen during the period of epithelial keratinization. Absence of phagocytosis in leucocytes at mestestrus suggested that leucocytes did not play an active role in reduction of bacterial numbers between estrus and metestrus. Accurate measurement of the pH in the vaginal lumen failed to reveal differences which could explain the reduction in bacterial numbers between estrus and metestrus. The cyclic changes in the bacterial population-consisting of species which are normally present in the intestinal flora-- seem to be controlled by cyclic changes in the amounts of cellular debris in the vaginal lumen.
T R Koiter; M P Hazenberg; P van der Schoot
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  202     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  IM    
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MeSH Terms
Bacteria / isolation & purification*
Hydrogen-Ion Concentration
Mice, Inbred Strains / anatomy & histology,  microbiology*,  physiology
Transplantation, Isogeneic
Vagina / anatomy & histology,  microbiology*,  transplantation

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