Document Detail


REGULATION OF ASCORBIC ACID AND OF XYLULOSE SYNTHESIS IN RAT-LIVER EXTRACTS. THE EFFECT OF STARVATION ON THE ENZYMES OF THE GLUCURONIC ACID PATHWAY.
MedLine Citation:
PMID:  14340084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The synthesis of ascorbic acid in rat-liver extracts is impaired during starvation, and more from glucuronolactone and glucuronate than from gulonate and gulonolactone. 2. The formation of xylulose from gulonate and from gulonolactone is greatly enhanced during starvation, whereas it is decreased from glucuronolactone and from glucuronate. 3. The activity of the enzymes of the glucuronic acid pathway during starvation has been determined in rat-liver preparations. Gulonolactone oxidase is decreased, NAD-linked gulonate dehydrogenase is enhanced, and uronolactonase, aldonolactonase and NADP-linked hexonate dehydrogenase are unchanged. 4. The impairment of ascorbic acid synthesis from gulonate observed during starvation can be accounted for by the depressed activity of gulonolactone oxidase. 5. The cause of the enhanced formation of xylulose has been located in the sedimentable fraction of liver homogenate. 6. The hypothesis is formulated of an increased utilization of the glucuronic acid pathway during starvation.
Authors:
F STIRPE; M COMPORTI
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  95     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1965 May 
Date Detail:
Created Date:  1965-12-01     Completed Date:  1996-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  354-62     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Oxidoreductases*
Ascorbic Acid*
Carbohydrate Metabolism*
Esterases*
Glucuronates*
Lactones*
Liver Extracts*
Metabolism*
NADP*
Pentoses*
Rats*
Research*
Starvation*
Chemical
Reg. No./Substance:
0/Glucuronates; 0/Lactones; 0/Liver Extracts; 0/Pentoses; 50-81-7/Ascorbic Acid; 53-59-8/NADP; EC 1.1.-/Alcohol Oxidoreductases; EC 3.1.-/Esterases
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