Document Detail

Regulation of arterial PCO2 during inhalation of CO2 in chickens.
MedLine Citation:
PMID:  24869     Owner:  NLM     Status:  MEDLINE    
Since CO2-sensitive intrapulmonary chemoreceptors have been shown to exist in the avian lung, we conducted a series of experiments to determine if birds could regulate PaCO2 when confronted with an inspired CO2 load. Chickens were anesthetized with either pentobarbital (30 or phenobarbital (160 The PICO2 was either increased or decreased in successive 7 torr steps between 0 and 35 torr. At each level of PICO2, steady-state measurements of PaCO2, PaO2 and [H+]a were made. In three of ten experiments, tidal volume and respiratory frequency were determined and minute ventilation calculated. Our results indicate that as PICO2 is varied between 0 and 21 torr, minute ventilation increases and arterial homeostasis of PCO2 and [H+] is maintained; as the PICO2 is increased above 21 torr, PaCO2 increases. We conclude that the isocapnic hyperpnea associated with inhalation of CO2 in chickens is a CO2-coupled phenomenon and that it is mediated by CO2-sensitive intrapulmonary chemoreceptors.
J L Osborne; G S Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  31     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / blood*
Chemoreceptor Cells / physiology*
Chickens / blood,  physiology*
Hydrogen-Ion Concentration
Lung / innervation
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide

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