Document Detail


Regulation of arterial PCO2 during inhalation of CO2 in chickens.
MedLine Citation:
PMID:  24869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since CO2-sensitive intrapulmonary chemoreceptors have been shown to exist in the avian lung, we conducted a series of experiments to determine if birds could regulate PaCO2 when confronted with an inspired CO2 load. Chickens were anesthetized with either pentobarbital (30 mg.kg-1) or phenobarbital (160 mg.kg-1). The PICO2 was either increased or decreased in successive 7 torr steps between 0 and 35 torr. At each level of PICO2, steady-state measurements of PaCO2, PaO2 and [H+]a were made. In three of ten experiments, tidal volume and respiratory frequency were determined and minute ventilation calculated. Our results indicate that as PICO2 is varied between 0 and 21 torr, minute ventilation increases and arterial homeostasis of PCO2 and [H+] is maintained; as the PICO2 is increased above 21 torr, PaCO2 increases. We conclude that the isocapnic hyperpnea associated with inhalation of CO2 in chickens is a CO2-coupled phenomenon and that it is mediated by CO2-sensitive intrapulmonary chemoreceptors.
Authors:
J L Osborne; G S Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  31     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Dioxide / blood*
Chemoreceptor Cells / physiology*
Chickens / blood,  physiology*
Hydrogen-Ion Concentration
Lung / innervation
Male
Respiration*
Tidal Volume
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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