Document Detail

Regulation of apoptosis by ubiquitination.
MedLine Citation:
PMID:  12752669     Owner:  NLM     Status:  MEDLINE    
Cell elimination through apoptosis, or programmed cell death, is an evolutionarily conserved central tenet of biology from embryological development to immune homeostasis. While many of the apoptotic signaling pathways have been elucidated, the relationship between ubiquitin and apoptosis is only beginning to be defined. In the past decade, many reports of polyubiquitin conjugation of key pro- and anti-apoptotic molecules have characterized ubiquitin as an essential regulatory modification targeting proteins for proteasomal degradation. However, recent work relating monoubiquitination and nonclassical polyubiquitin conjugation to apoptotic molecules has added an additional level of diversity to the role of ubiquitin in apoptotic regulation beyond degradation. This review focuses on the direct effects of ubiquitination on apoptosis-signaling molecules.
Justine C Lee; Marcus E Peter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  193     ISSN:  0105-2896     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2004-03-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
The Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA.
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MeSH Terms
Apoptosis / physiology*
Protein Processing, Post-Translational / physiology*
Proteins / metabolism
Signal Transduction / physiology*
Ubiquitins / metabolism*
Reg. No./Substance:
0/Proteins; 0/Ubiquitins

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