Document Detail

Regulation of angiogenesis in the endometrium.
MedLine Citation:
PMID:  11295569     Owner:  NLM     Status:  MEDLINE    
A crucial stage in pregnancy is the implantation of the embryo into the endometrium. The endometrium, which is situated in the lining of the uterus, is a complex structure consisting of a single epithelial layer overlying a mesenchymal stroma. Cyclical growth of the endometrium under the influence of ovarian steroids results in the establishment of a receptive endometrium. If implantation fails, or is deliberately prevented by the use of fertility regulation, the endometrium is shed by the process of menstruation. This unique system of cyclic tissue regeneration is dependent on the cyclical growth and regression of the blood vessels that supply the endometrium. Little attention has been paid to this crucial aspect of human reproduction but it now appears that many disorders that reduce the quality of life of modern women, such as heavy menstruation, endometriosis, breakthrough bleeding and infertility, might have their basis in disorders of the endometrial vasculature.
S K Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  12     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-04-11     Completed Date:  2001-07-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
The Rosie Hospital, Robinson Way, Dept of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK CB2 2SW.
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MeSH Terms
Endometriosis / etiology
Endometrium / blood supply*
Endothelial Growth Factors / physiology
Lymphokines / physiology
Menstrual Cycle
Neovascularization, Physiologic*
Uterine Hemorrhage / etiology
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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