Document Detail

Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
MedLine Citation:
PMID:  17573066     Owner:  NLM     Status:  MEDLINE    
Cell invasion is a tightly controlled process occurring during development and tumor progression. The nematode Caenorhabditis elegans serves as a genetic model to study cell invasion during normal development. In the third larval stage, the anchor cell in the somatic gonad first induces and then invades the adjacent epidermal vulval precursor cells. The homolog of the Evi-1 oncogene, egl-43, is necessary for basement membrane destruction and anchor cell invasion. egl-43 is part of a regulatory network mediating cell invasion downstream of the fos-1 proto-oncogene. In addition, EGL-43 is required to specify the cell fates of ventral uterus cells downstream of or in parallel with LIN-12 NOTCH. Comparison with mammalian Evi-1 suggests a conserved pathway controlling cell invasion and cell fate specification.
Ivo Rimann; Alex Hajnal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-25
Journal Detail:
Title:  Developmental biology     Volume:  308     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Institute of Zoology, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.
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MeSH Terms
Animals, Genetically Modified
Cadherins / genetics,  metabolism
Caenorhabditis elegans / cytology,  genetics*,  growth & development*,  metabolism
Caenorhabditis elegans Proteins / genetics*,  metabolism
Gene Expression Regulation, Developmental
Genes, Helminth
Models, Biological
Proto-Oncogene Proteins c-fos / genetics,  metabolism
RNA Interference
Transcription Factors / genetics*,  metabolism
Uterus / cytology,  growth & development,  metabolism
Reg. No./Substance:
0/CDH-3 protein, C elegans; 0/Cadherins; 0/Caenorhabditis elegans Proteins; 0/Egl-43 protein, C elegans; 0/FOS-1 protein, C elegans; 0/Proto-Oncogene Proteins c-fos; 0/Transcription Factors

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