Document Detail


Regulation of airway mucin gene expression.
MedLine Citation:
PMID:  17961085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucins are important components that exert a variety of functions in cell-cell interaction, epidermal growth factor receptor signaling, and airways protection. In the conducting airways of the lungs, mucins are the major contributor to the viscoelastic property of mucous secretion, which is the major barrier to trapping inhaled microbial organism, particulates, and oxidative pollutants. The homeostasis of mucin production is an important feature in conducting airways for the maintenance of mucociliary function. Aberrant mucin secretion and accumulation in airway lumen are clinical hallmarks associated with various lung diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, emphysema, and lung cancer. Among 20 known mucin genes identified, 11 of them have been verified at either the mRNA and/or protein level in airways. The regulation of mucin genes is complicated, as are the mediators and signaling pathways. This review summarizes the current view on the mediators, the signaling pathways, and the transcriptional units that are involved in the regulation of airway mucin gene expression. In addition, we also point out essential features of epigenetic mechanisms for the regulation of these genes.
Authors:
Philip Thai; Artem Loukoianov; Shinichiro Wachi; Reen Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  70     ISSN:  0066-4278     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-14     Completed Date:  2008-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-29     Citation Subset:  IM    
Affiliation:
Center for Comparative Respiratory Biology and Medicine, Division of Pulmonary and Critical Care, Department of Internal Medicine, University of California, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epigenesis, Genetic / physiology*
Gene Expression Regulation*
Humans
Lung / physiology*
Lung Diseases / genetics*,  physiopathology
Mucins / genetics*
Grant Support
ID/Acronym/Agency:
R01 HL077315/HL/NHLBI NIH HHS; R01 HL077902/HL/NHLBI NIH HHS; T32 HL07013/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Mucins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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