| Regulation of activation induced deaminase via phosphorylation. | |
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MedLine Citation:
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PMID: 17338181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunoglobulin gene diversification by somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion is dependent upon activation-induced cytidine deaminase (AID). AID is a single-stranded DNA specific cytidine deaminase that is expressed primarily in activated mature B lymphocytes. AID appears to catalyze DNA cytidine deamination of immunoglobulin heavy (IgH) and light chain (IgL) variable region (V) exons and IgH switch (S) region sequences to initiate, respectively, IgH and IgL somatic hypermutation (SHM) and IgH class switch recombination (CSR). Here, we will discuss the implications of recent studies that demonstrate the role of AID phosphorylation in augmenting AID activity with respect to these two processes. |
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Authors:
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Uttiya Basu; Jayanta Chaudhuri; Ryan T Phan; Abhishek Datta; Frederick W Alt |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 596 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-06 Completed Date: 2007-04-26 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 129-37 Citation Subset: IM |
Affiliation:
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The Howard Hughes Medical Institute, The Children's Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / enzymology Catalysis Cytidine Deaminase / metabolism* Deamination Flow Cytometry Humans Phosphorylation Protein Processing, Post-Translational |
| Grant Support | |
ID/Acronym/Agency:
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AI31541/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.-/AICDA (activation-induced cytidine deaminase); EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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