Document Detail

Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial.
MedLine Citation:
PMID:  20216555     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/OBJECTIVES: In spite of the much evidence for the beneficial effects of probiotics, their anti-obesity effects have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri SBT2055 (LG2055) on abdominal adiposity, body weight and other body measures in adults with obese tendencies.
SUBJECTS/METHODS: We conducted a multicenter, double-blind, randomized, placebo-controlled intervention trial. Subjects (n=87) with higher body mass index (BMI) (24.2-30.7 kg/m(2)) and abdominal visceral fat area (81.2-178.5 cm(2)) were randomly assigned to receive either fermented milk (FM) containing LG2055 (active FM; n=43) or FM without LG2055 (control FM; n=44), and were asked to consume 200 g/day of FM for 12 weeks. Abdominal fat area was determined by computed tomography.
RESULTS: In the active FM group, abdominal visceral and subcutaneous fat areas significantly (P<0.01) decreased from baseline by an average of 4.6% (mean (confidence interval): -5.8 (-10.0, -1.7) cm(2)) and 3.3% (-7.4 (-11.6, -3.1) cm(2)), respectively. Body weight and other measures also decreased significantly (P<0.001) as follows: body weight, 1.4% (-1.1 (-1.5, -0.7) kg); BMI, 1.5% (-0.4 (-0.5, -0.2) kg/m(2)); waist, 1.8% (-1.7 (-2.1, -1.4) cm); hip, 1.5% (-1.5 (-1.8, -1.1) cm). In the control group, by contrast, none of these parameters decreased significantly. High-molecular weight adiponectin in serum increased significantly (P<0.01) in the active and control groups by 12.7% (0.17 (0.07, 0.26) microg/ml) and 13.6% (0.23 (0.07, 0.38) microg/ml), respectively.
CONCLUSION: The probiotic LG2055 showed lowering effects on abdominal adiposity, body weight and other measures, suggesting its beneficial influence on metabolic disorders.
Y Kadooka; M Sato; K Imaizumi; A Ogawa; K Ikuyama; Y Akai; M Okano; M Kagoshima; T Tsuchida
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2010-03-10
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  64     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  636-43     Citation Subset:  IM    
Technology and Research Institute, Snow Brand Milk Products Co. Ltd., Kawagoe, Saitama, Japan.
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MeSH Terms
Abdominal Fat / metabolism*
Adiponectin / blood
Body Mass Index
Body Weight*
Double-Blind Method
Intra-Abdominal Fat / metabolism
Middle Aged
Obesity / drug therapy*,  metabolism
Obesity, Abdominal / drug therapy*,  metabolism
Probiotics / therapeutic use*
Subcutaneous Fat, Abdominal / metabolism
Waist Circumference
Reg. No./Substance:

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