Document Detail

Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells.
MedLine Citation:
PMID:  15002043     Owner:  NLM     Status:  MEDLINE    
T-cell death-associated gene 51 (TDAG51) has been described to regulate T-cell receptor/CD3-dependent induction of CD95/Fas and subsequent activation-induced cell death (AICD) in a murine T-cell hybridoma. Using well-defined pharmacological inhibitors, we investigated the regulation of TDAG51 expression in human T-cells and the correlation with cell death. TDAG51 was induced in resting T-cells, lymphoid cell lines and AICD-susceptible as well as AICD-resistant T-cell clones, and induction was inhibited by MAP-kinase inhibitors and PKC inhibitor Gö6983. No correlation between the effects of inhibitors on TDAG51 expression and cell death was observed. The constitutive TDAG51 expression in five pancreatic carcinoma cell lines was reduced by MAP-kinase inhibitors but not by Gö6983. Furthermore, the inducible overexpression of TDAG51 in TetOn Jurkat cells did not modulate cellular proliferation, phorbolester/ionomycin-induced growth arrest, or the expression of various cell surface molecules. Our results indicate that the expression of TDAG51 in human T-cells does not correlate with AICD.
H-H Oberg; B Sipos; H Kalthoff; O Janssen; D Kabelitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell death and differentiation     Volume:  11     ISSN:  1350-9047     ISO Abbreviation:  Cell Death Differ.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-19     Completed Date:  2005-01-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9437445     Medline TA:  Cell Death Differ     Country:  England    
Other Details:
Languages:  eng     Pagination:  674-84     Citation Subset:  IM    
Institute of Immunology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
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MeSH Terms
Apoptosis / physiology
Cell Division / physiology
Gene Expression Regulation / physiology*
Jurkat Cells
Mitogen-Activated Protein Kinases / metabolism
Protein Kinase C / metabolism
T-Lymphocytes / metabolism*
Time Factors
Transcription Factors / genetics*,  metabolism
Reg. No./Substance:
0/PHLDA1 protein, human; 0/Transcription Factors; EC Kinase C; EC Protein Kinases

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