| Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy. | |
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MedLine Citation:
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PMID: 19255118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal muscle atrophy is a severe consequence of ageing, neurological disorders and chronic disease. Identifying the intracellular signalling pathways controlling changes in skeletal muscle size and function is vital for the future development of potential therapeutic interventions. Striated activator of Rho signalling (STARS), an actin-binding protein, has been implicated in rodent cardiac hypertrophy; however its role in human skeletal muscle has not been determined. This study aimed to establish if STARS, as well as its downstream signalling targets, RhoA, myocardin-related transcription factors A and B (MRTF-A/B) and serum response factor (SRF), were increased and decreased respectively, in human quadriceps muscle biopsies taken after 8 weeks of both hypertrophy-stimulating resistance training and atrophy-stimulating de-training. The mRNA levels of the SRF target genes involved in muscle structure, function and growth, such as alpha-actin, myosin heavy chain IIa (MHCIIa) and insulin-like growth factor-1 (IGF-1), were also measured. Following resistance training, STARS, MRTF-A, MRTF-B, SRF, alpha-actin, MHCIIa and IGF-1 mRNA, as well as RhoA and nuclear SRF protein levels were all significantly increased by between 1.25- and 3.6-fold. Following the de-training period all measured targets, except for RhoA, which remained elevated, returned to base-line. Our results show that the STARS signalling pathway is responsive to changes in skeletal muscle loading and appears to play a role in both human skeletal muscle hypertrophy and atrophy. |
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Authors:
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Séverine Lamon; Marita A Wallace; Bertrand Léger; Aaron P Russell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-02 |
Journal Detail:
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Title: The Journal of physiology Volume: 587 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-16 Completed Date: 2009-07-15 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 1795-803 Citation Subset: IM |
Affiliation:
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Clinique Romande de Réadaptation SUVA Care, Sion 1951, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobic Threshold / physiology Atrophy Blotting, Western DNA Primers DNA-Binding Proteins / physiology Humans Hypertrophy Male Microfilament Proteins / physiology* Muscle, Skeletal / growth & development, pathology, physiology* Oncogene Proteins, Fusion / physiology Oxygen Consumption Physical Endurance / physiology Physical Fitness / physiology* RNA, Messenger / biosynthesis, genetics Reverse Transcriptase Polymerase Chain Reaction Serum Response Factor / physiology Signal Transduction / physiology* Tomography, X-Ray Computed Transcription Factors / physiology* Weight Lifting / physiology |
| Chemical | |
Reg. No./Substance:
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0/ABRA protein, human; 0/DNA Primers; 0/DNA-Binding Proteins; 0/MKL1 protein, human; 0/Microfilament Proteins; 0/Oncogene Proteins, Fusion; 0/RNA, Messenger; 0/Serum Response Factor; 0/Transcription Factors |
| Comments/Corrections | |
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