Document Detail


Regulation of S100B in white adipose tissue by obesity in mice.
MedLine Citation:
PMID:  25068089     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
S100B is a calcium binding protein found in adipose tissue; however, relatively little is known about the physiologic regulation or distribution of the protein within this organ. We examined plasma S100B concentration and white adipose tissue (WAT) s100b mRNA levels in lean and diet-induced obese (DIO) mice. Plasma S100B levels were increased by obesity. In WAT, s100b gene expression was also significantly increased by obesity and this increase was reversed following weight-loss. s100b gene expression was detected in both the adipocyte-enriched and stromal-vascular fractions of WAT; however, the increase in s100b gene expression in obese animals was only detected in the adipocyte-enriched fraction. Our results support published in vitro data indicating that WAT S100B may contribute to obesity-associated inflammation.
Authors:
Laura B Buckman; Emily K Anderson-Baucum; Alyssa H Hasty; Kate Lj Ellacott
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Publication Detail:
Type:  Journal Article     Date:  2014-04-04
Journal Detail:
Title:  Adipocyte     Volume:  3     ISSN:  2162-3945     ISO Abbreviation:  Adipocyte     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-28     Completed Date:  2014-07-28     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101567863     Medline TA:  Adipocyte     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-20     Citation Subset:  -    
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