Document Detail

Regulation of S phase.
MedLine Citation:
PMID:  16903207     Owner:  NLM     Status:  MEDLINE    
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of mechanisms to control this aspect of the cell cycle. There are various determinants of origin identification, as well as a large number of proteins required to load replication complexes at these defined genomic regions. A pre-Replication Complex (pre-RC) associates with origins in the G1 phase. This complex includes the Origin Recognition Complex (ORC), which serves to recognize origins, the putative helicase MCM2-7, and other factors important for complex assembly. Following pre-RC loading, a pre-Initiation Complex (pre-IC) builds upon the helicase with factors required for eventual loading of replicative polymerases. The chromatin association of these two complexes is temporally distinct, with pre-RC being inhibited, and pre-IC being activated by cyclin-dependent kinases (Cdks). This regulation is the basis for replication licensing, which allows replication to occur at a specific time once, and only once, per cell cycle. By preventing extra rounds of replication within a cell cycle, or by ensuring the cell cycle cannot progress until the environmental and intracellular conditions are most optimal, cells are able to carry out a successful replication cycle with minimal mutations.
Jamie K Teer; Anindya Dutta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  42     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-09-08     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  31-63     Citation Subset:  IM    
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MeSH Terms
Cyclin-Dependent Kinases / physiology
DNA Replication / genetics,  physiology*
Gene Expression Regulation / physiology
Origin Recognition Complex
Replication Origin
S Phase*
Grant Support
CA60499/CA/NCI NIH HHS; CA89406/CA/NCI NIH HHS; R01 CA060499/CA/NCI NIH HHS; R01 CA060499-13/CA/NCI NIH HHS; R01 CA089406/CA/NCI NIH HHS; R01 CA089406-07A2/CA/NCI NIH HHS; U01 HG003157/HG/NHGRI NIH HHS; U01 HG003157-03/HG/NHGRI NIH HHS
Reg. No./Substance:
0/Origin Recognition Complex; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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