| Regulation of S phase. | |
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MedLine Citation:
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PMID: 16903207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of mechanisms to control this aspect of the cell cycle. There are various determinants of origin identification, as well as a large number of proteins required to load replication complexes at these defined genomic regions. A pre-Replication Complex (pre-RC) associates with origins in the G1 phase. This complex includes the Origin Recognition Complex (ORC), which serves to recognize origins, the putative helicase MCM2-7, and other factors important for complex assembly. Following pre-RC loading, a pre-Initiation Complex (pre-IC) builds upon the helicase with factors required for eventual loading of replicative polymerases. The chromatin association of these two complexes is temporally distinct, with pre-RC being inhibited, and pre-IC being activated by cyclin-dependent kinases (Cdks). This regulation is the basis for replication licensing, which allows replication to occur at a specific time once, and only once, per cell cycle. By preventing extra rounds of replication within a cell cycle, or by ensuring the cell cycle cannot progress until the environmental and intracellular conditions are most optimal, cells are able to carry out a successful replication cycle with minimal mutations. |
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Authors:
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Jamie K Teer; Anindya Dutta |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Results and problems in cell differentiation Volume: 42 ISSN: 0080-1844 ISO Abbreviation: Results Probl Cell Differ Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-14 Completed Date: 2006-09-08 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0173555 Medline TA: Results Probl Cell Differ Country: Germany |
Other Details:
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Languages: eng Pagination: 31-63 Citation Subset: IM |
Affiliation:
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Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclin-Dependent Kinases / physiology DNA Replication / genetics, physiology* Gene Expression Regulation / physiology Humans Origin Recognition Complex Replication Origin S Phase* |
| Grant Support | |
ID/Acronym/Agency:
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CA60499/CA/NCI NIH HHS; CA89406/CA/NCI NIH HHS; R01 CA060499-13/CA/NCI NIH HHS; R01 CA089406-07A2/CA/NCI NIH HHS; R01 CA089406-10/CA/NCI NIH HHS; U01 HG003157-03/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Origin Recognition Complex; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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