Document Detail

Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications.
MedLine Citation:
PMID:  20936940     Owner:  NLM     Status:  MEDLINE    
NaCl absorption along the nephron is regulated not just by humoral factors but also by factors that do not circulate or act on the cells where they are produced. Generally, nitric oxide (NO) inhibits NaCl absorption along the nephron. However, the effects of NO in the proximal tubule are controversial and may be biphasic. Similarly, the effects of endothelin on proximal tubule transport are biphasic. In more distal segments, endothelin inhibits NaCl absorption and may be mediated by NO. Adenosine triphosphate (ATP) inhibits sodium bicarbonate absorption in the proximal tubule, NaCl absorption in thick ascending limbs via NO, and water reabsorption in collecting ducts. Defects in the effects of NO, endothelin, and ATP increase blood pressure, especially in a NaCl-sensitive manner. In diabetes, disruption of NO-induced inhibition of transport may contribute to increased blood pressure and renal damage. However, our understanding of how NO, endothelin, and ATP work, and of their role in pathology, is rudimentary at best.
Jeffrey L Garvin; Marcela Herrera; Pablo A Ortiz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  73     ISSN:  1545-1585     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-07-08     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-76     Citation Subset:  IM    
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MeSH Terms
Absorption / physiology
Adenosine Triphosphate / physiology*
Biological Transport / physiology
Diabetic Nephropathies / physiopathology
Endothelins / physiology*
Kidney / physiology*
Nitric Oxide / physiology*
Sodium Bicarbonate / metabolism
Sodium Chloride / metabolism*
Reg. No./Substance:
0/Endothelins; 31C4KY9ESH/Nitric Oxide; 7647-14-5/Sodium Chloride; 8L70Q75FXE/Adenosine Triphosphate; 8MDF5V39QO/Sodium Bicarbonate

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