| Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications. | |
| | |
MedLine Citation:
|
PMID: 20936940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
NaCl absorption along the nephron is regulated not just by humoral factors but also by factors that do not circulate or act on the cells where they are produced. Generally, nitric oxide (NO) inhibits NaCl absorption along the nephron. However, the effects of NO in the proximal tubule are controversial and may be biphasic. Similarly, the effects of endothelin on proximal tubule transport are biphasic. In more distal segments, endothelin inhibits NaCl absorption and may be mediated by NO. Adenosine triphosphate (ATP) inhibits sodium bicarbonate absorption in the proximal tubule, NaCl absorption in thick ascending limbs via NO, and water reabsorption in collecting ducts. Defects in the effects of NO, endothelin, and ATP increase blood pressure, especially in a NaCl-sensitive manner. In diabetes, disruption of NO-induced inhibition of transport may contribute to increased blood pressure and renal damage. However, our understanding of how NO, endothelin, and ATP work, and of their role in pathology, is rudimentary at best. |
| | |
Authors:
|
Jeffrey L Garvin; Marcela Herrera; Pablo A Ortiz |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Annual review of physiology Volume: 73 ISSN: 1545-1585 ISO Abbreviation: Annu. Rev. Physiol. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-02-14 Completed Date: 2011-07-08 Revised Date: 2012-03-22 |
Medline Journal Info:
|
Nlm Unique ID: 0370600 Medline TA: Annu Rev Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 359-76 Citation Subset: IM |
Affiliation:
|
Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA. jgarvin1@hfhs.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption
/
physiology Adenosine Triphosphate / physiology* Animals Biological Transport / physiology Diabetic Nephropathies / physiopathology Endothelins / physiology* Humans Kidney / physiology* Mice Nitric Oxide / physiology* Rats Sodium Bicarbonate / metabolism Sodium Chloride / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Endothelins; 10102-43-9/Nitric Oxide; 144-55-8/Sodium Bicarbonate; 56-65-5/Adenosine Triphosphate; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renin release: sites, mechanisms, and control.
Next Document: Tight junction pore and leak pathways: a dynamic duo.