Document Detail

Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.
MedLine Citation:
PMID:  23034942     Owner:  NLM     Status:  MEDLINE    
The activity of the renal thiazide-sensitive NaCl cotransporter (NCC) in the distal convoluted tubule plays a key role in defining arterial blood pressure levels. Increased or decreased activity of the NCC is associated with arterial hypertension or hypotension, respectively. Thus it is of major interest to understand the activity of NCC using in vivo models. Phosphorylation of certain residues of the amino-terminal domain of NCC has been shown to be associated with its activation. The development of phospho-specific antibodies against these sites provides a powerful tool that is helping to increase our understanding of the molecular physiology of NCC. Additionally, NCC expression in the plasma membrane is modulated by ubiquitylation, which represents another major mechanism for regulating protein activity. This work presents a review of our current knowledge of the regulation of NCC activity by phosphorylation and ubiquitylation.
Gerardo Gamba
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-03
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  303     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-04-02     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F1573-83     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology
Diet, Sodium-Restricted
Insulin / physiology
Kidney / physiology*
Kidney Tubules, Distal / physiology
Phosphorylation / physiology*
Sodium Chloride Symporters / physiology*
Ubiquitination / physiology*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Insulin; 0/Sodium Chloride Symporters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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