| Regulation of Ras signaling by the cell cycle. | |
| | |
MedLine Citation:
|
PMID: 11790553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is well known that upregulation of Ras activity can promote cell-cycle progression. Now recent studies indicate that a reciprocal relationship also exists; that is, the consequences of Ras signaling are dependent upon cell-cycle position. In quiescent cells stimulated with growth factors, one Ras effector, phosphatidylinositol-3-kinase, is activated twice as cells transition from G(0) into G(1) phase, and then later in G(1) phase. It is only during the later stages of G(1) phase that PI3K activity promotes entry into S-phase. In cycling cells, Ras activity is enhanced throughout the cell cycle, but is able to stimulate cyclin D1 elevation only during G(2) phase. |
| | |
Authors:
|
Dennis Stacey; Andrius Kazlauskas |
Related Documents
:
|
17320423 - Enrichment of epidermal stem cells by rapid adherence and analysis of the reciprocal in... 12818243 - 3-deazauridine triggers dose-dependent apoptosis in myeloid leukemia cells and enhances... 23116613 - The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell p... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in genetics & development Volume: 12 ISSN: 0959-437X ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2002 Feb |
Date Detail:
|
Created Date: 2002-01-15 Completed Date: 2002-04-11 Revised Date: 2011-06-06 |
Medline Journal Info:
|
Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
|
Languages: eng Pagination: 44-6 Citation Subset: IM |
Affiliation:
|
Department of Molecular Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle / physiology* Cyclin D1 / metabolism G0 Phase G1 Phase Gene Expression Regulation Humans Phosphatidylinositol 3-Kinases / physiology Proto-Oncogene Proteins c-raf / physiology S Phase Signal Transduction / physiology* ral Guanine Nucleotide Exchange Factor / physiology ras Proteins / metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 EY012509-12/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/ral Guanine Nucleotide Exchange Factor; 136601-57-5/Cyclin D1; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-raf; EC 3.6.5.2/ras Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Advances in Rho-dependent actin regulation and oncogenic transformation.
Next Document: Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes.