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Regulation of PAF-induced platelet responses by cyclic nucleotides.
MedLine Citation:
PMID:  20297936     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The existence of cross-talk mechanisms between the cyclic nucleotide system and other transduction systems involved in PAF-activated platelets is described in this study. A protein of 125 kDa, identified as pp 125(FAK), is tyrosine phosphorylated by PAF in a time- and concentration-dependent manner. The presence of a cAMP- or a cGMP-elevating agent, used alone or in combination, together with PAF diminished tyrosine phosphorylation. The sensitivity to cAMP shown by PAF-induced ppl25 phosphorylation on tyrosine residues was similar to PAF-induced phosphorylation of a 47-kDa protein (pp47) on serine and threonine. In contrast, the latter was not affected in the presence of a cGMP-elevating agent, although it was able to enhance synergistically the inhibitory effect of forskolin. Data reported herein also show that pp47 phosphorylation and serotonin secretion are not closely correlated. Accordingly, sodium nitroprusside (SNP) did not have any effect on phosphorylation of pp47, but it was able to inhibit serotonin secretion when added alone, and it showed a synergistic inhibitory action with forskolin.
Authors:
R E Catalán; A M Martínez; M D Aragonés; M Lombardía; M C Calcerrada; E Garde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Platelets     Volume:  8     ISSN:  0953-7104     ISO Abbreviation:  Platelets     Publication Date:  1997  
Date Detail:
Created Date:  2010-03-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208117     Medline TA:  Platelets     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  -    
Affiliation:
Departamento de Biología Molecular, Centra de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autónoma de Madrid, E-28049, Madrid, Spain.
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