| Regulation of macrophage and dendritic cell responses by their lineage precursors. | |
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MedLine Citation:
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PMID: 22433183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue macrophages (Mø) and dendritic cells (DC) are thought to derive from hematopoietic stem cells, which exist in the bone marrow and generate intermediate precursor populations with increasingly restricted lineage potentials. There exists several precursors committed to the Mø and DC lineages; these cells exhibit distinct tropism and function and respond differentially in pathophysiologic conditions. In this review, we consider experimental contexts in which Mø and DC responses in tissue are not only dictated by the local environment, but also by the quantity and quality of newly recruited lineage precursor cells. Consequently, we discuss whether therapeutic control of Mø and DC responses in tissue may be achieved through manipulation of their lineage precursors. |
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Authors:
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Virna Cortez-Retamozo; Martin Etzrodt; Mikael J Pittet |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-03-16 |
Journal Detail:
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Title: Journal of innate immunity Volume: 4 ISSN: 1662-8128 ISO Abbreviation: J Innate Immun Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-05 Completed Date: 2013-01-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101469471 Medline TA: J Innate Immun Country: Switzerland |
Other Details:
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Languages: eng Pagination: 411-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Lineage / immunology* Dendritic Cells / cytology, immunology* Humans Macrophages / cytology, immunology* Mice Myeloid Progenitor Cells / cytology, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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HHSN268201000044C.//PHS HHS; N01-HV08235/HV/NHLBI NIH HHS; P50 CA086355/CA/NCI NIH HHS; P50-CA086355/CA/NCI NIH HHS; R01 AI084880/AI/NIAID NIH HHS; R01 CA096978/CA/NCI NIH HHS; R01-AI084880/AI/NIAID NIH HHS; R56 AI084880/AI/NIAID NIH HHS |
| Comments/Corrections | |
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