| Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation. | |
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MedLine Citation:
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PMID: 17012840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it is well established that a transient activation of the mitogen-activated protein kinases Erk and Jnk is a crucial step in most growth promoting signaling pathways, it has also been demonstrated that a prolonged activation of these kinases can induce differentiation, cell cycle arrest, and cell senescence. We recently found that the expression of the 21-kDa human Vaccinia H1-related (VHR) dual-specific phosphatase fluctuates during cell cycle progression and affects Erk and Jnk activity in a cell cycle-dependent manner. Cells lacking VHR arrested at the G(1)/S and G(2)/M transitions of the cell cycle and exhibited senescence phenotypes. Cells lacking VHR upregulated p21(Cip/Waf1) and downregulated many genes for cell cycle regulators, DNA replication, transcription, and mRNA processing. In the absence of VHR, the serum-induced activation of Jnk and Erk was further elevated and was required for the G(1)/S and G(2)/M blocks, which were attenuated upon Jnk and Erk inhibition. Collectively, VHR provides a long sought layer in the regulation of Jnk and Erk during cell cycle progression thereby contributing to cell cycle arrest, differentiation or senescence. |
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Authors:
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Fabio Cerignoli; Souad Rahmouni; Ze'ev Ronai; Tomas Mustelin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2006-10-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-19 Completed Date: 2007-01-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2210-5 Citation Subset: IM |
Affiliation:
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The Burnham Institute for Medical Research, La Jolla, California 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Cell Cycle Proteins Cell Differentiation Cell Proliferation Dual Specificity Phosphatase 3 Feedback, Physiological / physiology* Humans Mitogen-Activated Protein Kinases / metabolism*, physiology Protein Tyrosine Phosphatases / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AI35603/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.1.3.48/DUSP3 protein, human; EC 3.1.3.48/Dual Specificity Phosphatase 3; EC 3.1.3.48/Protein Tyrosine Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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