| Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase expression by Zingiber officinale in the liver of high-fat diet-fed rats. | |
| | |
MedLine Citation:
|
PMID: 20002065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Zingiber officinale has been used to control lipid disorders and reported to possess remarkable cholesterol-lowering activity in experimental hyperlipidaemia. In the present study, the effect of a characterized and standardized extract of Zingiber officinale on the hepatic lipid levels as well as on the hepatic mRNA and protein expression of low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was investigated in a high-fat diet-fed rat model. Rats were treated with an ethanol extract of Zingiber officinale (400 mg/kg) extract along with a high-fat diet for 6 weeks. The extract of Zingiber officinale significantly decreased hepatic triglyceride and tended to decrease hepatic cholesterol levels when administered over 6 weeks to the rats fed a high-fat diet. We found that in parallel, the extract up-regulated both LDL receptor mRNA and protein level and down-regulated HMG-CoA reductase protein expression in the liver of these rats. The metabolic control of body lipid homeostasis is in part due to enhanced cholesterol biosynthesis and reduced expression of LDL receptor sites following long-term consumption of high-fat diets. The present results show restoration of transcriptional and post-transcriptional changes in low-density lipoprotein and HMG CoA reductase by Zingiber officinale administration with a high-fat diet and provide a rational explanation for the effect of ginger in the treatment of hyperlipidaemia. |
| | |
Authors:
|
Srinivas Nammi; Moon S Kim; Navnath S Gavande; George Q Li; Basil D Roufogalis |
Related Documents
:
|
16089355 - Assessment of modes of action and efficacy of plasma cholesterol-lowering drugs: measur... 6713595 - Hepatic cholesterol in lead nitrate induced liver hyperplasia. 2595265 - Dissociation of changes in plasma cholesterol and hepatic cholesterol synthesis, assess... 8510515 - The role of cholesterol absorption and hepatic cholesterol content in high and low resp... 16089355 - Assessment of modes of action and efficacy of plasma cholesterol-lowering drugs: measur... 16050115 - Isomaltooligosaccharide increases cecal bifidobacterium population in young broiler chi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-07 |
Journal Detail:
|
Title: Basic & clinical pharmacology & toxicology Volume: 106 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-06-07 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 389-95 Citation Subset: IM |
Affiliation:
|
Herbal Medicines Research & Education Centre, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia. snammi@pharm.usyd.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholesterol / metabolism Diet Dietary Fats / administration & dosage Ethanol / chemistry Fats / metabolism Ginger / chemistry* Hydroxymethylglutaryl CoA Reductases / biosynthesis, genetics, metabolism* Lipoproteins, LDL / metabolism Liver / drug effects*, enzymology, metabolism Plant Extracts / chemistry, pharmacology RNA, Messenger / metabolism Rats Receptors, LDL / biosynthesis, genetics, metabolism* Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Fats; 0/Lipoproteins, LDL; 0/Plant Extracts; 0/RNA, Messenger; 0/Receptors, LDL; 0/Triglycerides; 57-88-5/Cholesterol; 64-17-5/Ethanol; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification Sy...
Next Document: Exercise and Supraphysiological Dose of Nandrolone Deconoate increase Apoptosis in Spermatogenic Cel...