Document Detail

The Regulation, Localization and Functions of Oxygen Sensing Prolyl Hydroxylase Phd3.
MedLine Citation:
PMID:  23380539     Owner:  NLM     Status:  Publisher    
Abstract PHD3 prolyl 4-hydroxylase belongs to 2-oxoglutarate and iron-dependent dioxygenases. Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypoxia-inducible factor-alpha (HIF-α) for pVHL-mediated proteasomal destruction. Although having overlapping functions with PHD1 and PHD2, PHD3 markedly differs from the two isoforms. PHD3 shows different expression pattern and subcellular localization as well as activity under low oxygen tension. Moreover, it has the widest range of non-HIF targets underlying its diverse functions. The functions of PHD3 differ depending on the cell type but also partially on the microenvironmental conditions it is expressed at. Under normoxia PHD3 has been shown to be pro-apoptotic but under hypoxia it can have cell survival or proliferation supporting functions. Here we discuss the regulation, targets and functions of PHD3.
Panu M Jaakkola; Krista Rantanen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-6
Journal Detail:
Title:  Biological chemistry     Volume:  -     ISSN:  1437-4315     ISO Abbreviation:  Biol. Chem.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700112     Medline TA:  Biol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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