Document Detail


Regulation of jaw-specific isoforms of myosin-binding protein-C and tropomyosin in regenerating cat temporalis muscle innervated by limb fast and slow motor nerves.
MedLine Citation:
PMID:  20679518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cat jaw-closing muscles are a distinct muscle allotype characterized by the expression of masticatory-specific myofibrillar proteins. Transplantation studies showed that expression of masticatory myosin heavy chain (m-MyHC) is promoted by fast motor nerves, but suppressed by slow motor nerves. We investigated whether masticatory myosin-binding protein-C (m-MBP-C) and masticatory tropomyosin (m-Tm) are similarly regulated. Temporalis muscle strips were transplanted into limb muscle beds to allow innervation by fast or slow muscle nerve during regeneration. Regenerated muscles were examined postoperatively up to 168 days by peroxidase IHC using monoclonal antibodies to m-MyHC, m-MBP-C, and m-Tm. Regenerates in both muscle beds expressed fetal and slow MyHCs, m-MyHC, m-MBP-C, and m-Tm during the first 4 weeks. Longer-term regenerates innervated by fast nerve suppressed fetal and slow MyHCs, retaining m-MyHC, m-MBP-C, and m-Tm, whereas fibers innervated by slow nerve suppressed fetal MyHCs and the three masticatory-specific proteins, induced slow MyHC, and showed immunohistochemical characteristics of jaw-slow fibers. We concluded that expression of m-MBP-C and m-Tm is coregulated by m-MyHC and that neural impulses to limb slow muscle are capable of suppressing masticatory-specific proteins and to channel gene expression along the jaw-slow phenotype unique to jaw-closing muscle.
Authors:
Lucia H D Kang; Joseph F Y Hoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-02
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  58     ISSN:  1551-5044     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-11-12     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  989-1004     Citation Subset:  IM    
Affiliation:
Discipline of Physiology, Building F13, Sydney Medical School, The University of Sydney, Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / metabolism*
Cats
Extremities / innervation*
Gene Expression Regulation
Jaw / metabolism*
Movement*
Organ Specificity
Phenotype
Protein Isoforms / metabolism
Regeneration*
Temporal Muscle / innervation,  metabolism,  physiology*
Time Factors
Tropomyosin / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Protein Isoforms; 0/Tropomyosin; 0/myosin-binding protein C
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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