Document Detail


Regulation of IgE antibody production by serum molecules. VI: Preliminary biochemical and immunological characterization of serum molecules active in suppressing IgE antibody production.
MedLine Citation:
PMID:  262448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molecules present in the serum and ascites fluids of low IgE responder mice previously inoculated with complete Freund's adjuvant have been analyzed in terms of certain biochemical and immunological characteristics. These studies demonstrate that the active molecules, termed "suppressive factors of allergy" (SFA), are (1) nondialyzable, (2) not associated with low-density or high-density lipoproteins, (3) heat stable, (4) precipitable by ammonium sulfate, and (5) approximately 150,000 daltons in molecular size. Studies with immunoadsorbents prepared from various antisera indicate that the suppressive molecules are (1) not immunoglobulin in nature, (2) not reactive with specific anti-H-2 alloantibodies, but (3) reactive with anti-beta 2m antibodies as well as (4) heterologous antisera raised against CFA-immune mouse serum.
Authors:
D H Katz; A S Tung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunopharmacology     Volume:  1     ISSN:  0162-3109     ISO Abbreviation:  Immunopharmacology     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902474     Medline TA:  Immunopharmacology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Antibody Reactions
Ascitic Fluid / immunology*
Blood Proteins / analysis,  immunology*,  pharmacology
Depression, Chemical
Immunoglobulin E / biosynthesis*
Immunosuppressive Agents*
Mice
Molecular Weight
Rabbits
Grant Support
ID/Acronym/Agency:
AI-13874/AI/NIAID NIH HHS; RRO-5514/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Immunosuppressive Agents; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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