| Regulation of IgE and IgG4 synthesis in patients with hyper IgE syndrome. | |
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MedLine Citation:
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PMID: 2116376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the imbalance of IgG subclasses and its relationship to IgE level, 14 patients with hyper IgE syndrome (HIE syndrome) were examined for serum IgG subclasses and IgE levels and five of these patients were studied for in vitro IgE and IgG subclass production by peripheral blood lymphocytes (PBL) in response to interleukin-4 (IL-4)/interferon-gamma (IFN-gamma). Serum IgE levels were highly correlative with serum IgG4 levels (r = 0.75, P less than 0.005), but not with IgG1, IgG2 or IgG3 levels (r = 0.21, 0.43 and 0.41, respectively). In an in vitro study, recombinant IL-4 enhanced not only spontaneous IgE synthesis but also IgG4 synthesis in cultures of PBL from patients with HIE syndrome as well as in healthy donors (P less than 0.01), and the effect of recombinant IL-4 on both IgE and IgG4 synthesis was inhibited by low concentrations of recombinant IFN-gamma (P less than 0.01). The disturbed regulation of IgE and IgG4 seen in patients with hyper IgE syndrome may be caused mainly by the disturbed regulation of both cytokines. |
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Authors:
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A Ishizaka; K Joh; R Shibata; Y Wagatsuma; M Nakanishi; K Tomizawa; K Kojima; E Kandil; Y Sakiyama; S Matsumoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunology Volume: 70 ISSN: 0019-2805 ISO Abbreviation: Immunology Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-09-07 Completed Date: 1990-09-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 414-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cells, Cultured Child Child, Preschool Dermatitis / immunology* Humans Hypergammaglobulinemia / immunology* Immunoglobulin E / biosynthesis* Immunoglobulin G / biosynthesis* Infant Interferon-gamma, Recombinant / pharmacology Interleukin-4 / pharmacology Lymphocytes / drug effects, immunology Recombinant Proteins / pharmacology Staphylococcal Infections / immunology* Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Interferon-gamma, Recombinant; 0/Recombinant Proteins; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
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