| Regulation of Hypoxia Inducible Factors (HIF) in Hypoxia and Normoxia During Placental Development. | |
| | |
MedLine Citation:
|
PMID: 20869770 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia Inducible Factors (HIF) are the main regulators in the transcription of a number of genes. Target genes can induce anaerobic processes, reducing oxygen consumption, or promote angiogenesis, which establishes and enhances the vascular environment. The HIFs can function throughout all stages of placental differentiation and growth both in normal and pathological pregnancies (compromised by hypoxia/ischemia). Interestingly, HIFs respond to a multitude of changes during pregnancy, including 1) low oxygen, 2) renin-angiotensin system (RAS), 3) cytokines, and 4) growth factors, all of which regulate placental function. This review explores oxygen-dependent and oxygen-independent regulation and the role of HIF in placental development and differentiation. |
| | |
Authors:
|
J Patel; K Landers; R H Mortimer; K Richard |
Publication Detail:
|
Type: Journal Article Date: 2010-09-24 |
Journal Detail:
|
Title: Placenta Volume: 31 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
|
Languages: eng Pagination: 951-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
School of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital, Herston, Queensland 4029, Australia. jatin.patel@qimr.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized ?-tricalcium ...
Next Document: t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL.