Document Detail


Regulation and function of autophagy during cell survival and cell death.
MedLine Citation:
PMID:  22661635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy is an important catabolic process that delivers cytoplasmic material to the lysosome for degradation. Autophagy promotes cell survival by elimination of damaged organelles and proteins aggregates, as well as by facilitating bioenergetic homeostasis. Although autophagy has been considered a cell survival mechanism, recent studies have shown that autophagy can promote cell death. The core mechanisms that control autophagy are conserved between yeast and humans, but animals also possess genes that regulate autophagy that are not present in yeast. These regulatory differences may be explained by the need to control autophagy in a cell context-specific manner in multicellular animals, such as during cell survival and cell death. Autophagy was thought to be a bulk cytoplasmic degradation mechanism, but recent studies have shown that specific cargo is recruited for degradation. This suggests the possibility that either cell survival or death may be regulated by selective autophagic clearance of cytoplasmic material. Here we summarize the mechanisms that regulate autophagy and how they may contribute to cell survival and death.
Authors:
Gautam Das; Bhupendra V Shravage; Eric H Baehrecke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-06-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  4     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-11     Revised Date:  2014-01-29    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy* / genetics
Caspases / metabolism
Cell Death*
Cell Survival*
Grant Support
ID/Acronym/Agency:
CA159314/CA/NCI NIH HHS; GM079431/GM/NIGMS NIH HHS; R01 CA159314/CA/NCI NIH HHS; R01 GM079431/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.22.-/Caspases
Comments/Corrections

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