| Regulation of Fertility by the p53 Family Members. | |
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MedLine Citation:
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PMID: 21779510 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The p53 family members, which consist of 3 transcription factors-p53, p63, and p73-are conserved during evolution. The p53 family proteins are involved in many important cellular functions, including tumor suppression (p53 and p73), the development of epithelial cell layers (p63), and the development of central nervous system and immune system (p73). Studies on p53-like proteins in low organisms have demonstrated that their primordial functions are to maintain the genomic integrity of germ cells and ensure faithful development and reproduction. In vertebrates, the p53 family proteins retain these functions in reproduction and at the same time have developed additional important functions in reproduction, such as the regulation of embryonic implantation (p53). p53 regulates embryonic implantation through transcriptional regulation of leukemia inhibitory factor (LIF). p63, in particular TAp63, is a main regulator to protect the fidelity of female germ cells during meiotic arrest. p73, in particular TAp73, regulates the ovary function and the quality of oocytes. Loss of p53, p63, or p73 genes in female mice leads to a significant decrease in fertility. These functions of the p53 family proteins in reproduction provide a plausible explanation for positive evolutionary selection observed in a group of single nucleotide polymorphisms and haplotypes in the p53 family genes. A better understanding of the functions of the p53 family proteins in reproduction may lead to new strategies for fertility treatment. |
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Authors:
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Wenwei Hu; Tongsen Zheng; Jiabei Wang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Genes & cancer Volume: 2 ISSN: 1947-6027 ISO Abbreviation: Genes Cancer Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-07-22 Completed Date: 2011-11-10 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 101516546 Medline TA: Genes Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 420-30 Citation Subset: - |
Affiliation:
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Department of Pediatrics, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P30 CA147892/CA/NCI NIH HHS; P30 CA147892-01/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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