Document Detail

Regulation of FSH secretion: use of hydroxyurea to deplete germinal epithelium.
MedLine Citation:
PMID:  1116475     Owner:  NLM     Status:  MEDLINE    
Hydroxyurea, a chemotherapeutic agent that prevents mitosis by inhibiting DNA synthesis, was administered to adult male rats for 70 days. Plasma FSH and LH showed no systematic trend although severe germinal cell depletion was produced. These data suggest that the cell(s) of the seminiferous tubule involved in FSH regulation must be either the type A spermatogonium or the Sertoli cell.
R S Mecklenburg; W D Hetzel; B J Gulyas; M B Lipsett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  96     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-06-09     Completed Date:  1975-06-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  564-70     Citation Subset:  AIM; IM    
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MeSH Terms
Follicle Stimulating Hormone / blood,  secretion*
Hydroxyurea / pharmacology*
Luteinizing Hormone / blood
Testis / cytology*
Time Factors
Reg. No./Substance:
127-07-1/Hydroxyurea; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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