| Regulation of FSH secretion: use of hydroxyurea to deplete germinal epithelium. | |
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MedLine Citation:
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PMID: 1116475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydroxyurea, a chemotherapeutic agent that prevents mitosis by inhibiting DNA synthesis, was administered to adult male rats for 70 days. Plasma FSH and LH showed no systematic trend although severe germinal cell depletion was produced. These data suggest that the cell(s) of the seminiferous tubule involved in FSH regulation must be either the type A spermatogonium or the Sertoli cell. |
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Authors:
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R S Mecklenburg; W D Hetzel; B J Gulyas; M B Lipsett |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinology Volume: 96 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1975 Mar |
Date Detail:
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Created Date: 1975-06-09 Completed Date: 1975-06-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 564-70 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Follicle Stimulating Hormone / blood, secretion* Hydroxyurea / pharmacology* Luteinizing Hormone / blood Male Mitosis Radioimmunoassay Rats Testis / cytology* Time Factors |
| Chemical | |
Reg. No./Substance:
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127-07-1/Hydroxyurea; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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