| Regulation of the FSH Receptor in the Ovary. | |
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MedLine Citation:
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PMID: 10370228 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The follicle-stimulating hormone receptor (FSHR) is found exclusively on granulosa cells from as early as the two-layer or primary stage of folliculogenesis. Up to four alternatively spliced transcripts have been described. An increase in steady-state levels of FSHR mRNA as well as a change in alternative splicing appear to be important during early folliculogenesis. FSHRs remain on the granulosa cells of healthy follicles until they become atretic or luteinize, with relatively little change in receptor number per cell. Factors that increase expression are FSH itself, cAMP and its analogs, activin and transforming growth factor beta (TGF-beta), whereas epidermal growth factor (EGF)/TGF-alpha decrease expression. The regulatory regions of the FSHR gene are more akin to 'housekeeping' genes than to a highly regulated gene, and there is an E box in the promoter region. Regulation of the initial expression of FSHR mRNA at the two-granulosa cell layer stage of folliculogenesis is not understood. It will also be important to understand whether the alternatively spliced FSHR transcripts and their prevalence in the ovary during early folliculogenesis represent a biologically important phenomenon. |
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Authors:
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Findlay; Drummond |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 10 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-06-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: 183-188 Citation Subset: - |
Affiliation:
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Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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