| Regulation of complement activity via the alternative pathway in placentas of mouse spontaneous abortions. | |
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MedLine Citation:
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PMID: 20484840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental complement has the potential to induce autologous embryo injury. We have previously found a significant elevation of adipsin, an activating factor of the alternative complement pathway, in mouse placentas from spontaneous abortions. The present study was aimed to evaluate regulation of the alternative complement pathway in placentas of mouse spontaneous abortions. Protein was purified from mouse placentas at normal and abortion implantation sites on day 14.5 of pregnancy. The activity of the alternative complement pathway was slightly intensified following addition of protein from abortion placentas. Western blotting revealed that Crry was clearly present in the placentas from abortions. Thus, the complement regulating system through Crry is functional to restrict alternative complement activity in abortion placentas. |
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Authors:
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Ai Takeshita; Shota Nagaishi; Tomohiro Kondo; Toshiya Okada; Ken Takeshi Kusakabe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-18 |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 72 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1375-7 Citation Subset: IM |
Affiliation:
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Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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blood,
physiopathology* Animals Complement Pathway, Alternative Complement System Proteins / metabolism* Female Mice Placenta / metabolism, physiopathology* Pregnancy Pregnancy Proteins / metabolism Receptors, Complement / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Crry protein, mouse; 0/Pregnancy Proteins; 0/Receptors, Complement; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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