Document Detail

Regulation of cholesterol and fatty acid synthesis.
MedLine Citation:
PMID:  21504873     Owner:  NLM     Status:  MEDLINE    
In mammals, intracellular levels of cholesterol and fatty acids are controlled through a feedback regulatory system mediated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs). SREBPs are synthesized as inactive precursors bound to membranes of the endoplasmic reticulum. When cells are deprived of cholesterol and fatty acids, NH(2)-terminal fragments of SREBPs become proteolytically released from membranes and migrate to the nucleus to activate transcription of genes required for lipid synthesis and uptake. Conversely, lipid repletion inhibits proteolytic processing of SREBPs and thereby suppresses lipid accumulation. We review here studies in cultured cells that reveal the mechanism for regulation of SREBP proteolytic activation, and those in animal models in which SREBP proteolysis has been either activated or inhibited to show the essential role of SREBPs in regulating hepatic lipid homeostasis.
Jin Ye; Russell A DeBose-Boyd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-07-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  3     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-11-07     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
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MeSH Terms
Cells, Cultured
Cholesterol / biosynthesis*,  metabolism
Fatty Acids / biosynthesis*,  metabolism
Intracellular Signaling Peptides and Proteins / metabolism,  physiology
Liver / metabolism
Membrane Proteins / physiology
Models, Biological
Protein Isoforms / metabolism,  physiology
Sterol Regulatory Element Binding Proteins / metabolism,  physiology*
Grant Support
R01 GM090216/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Fatty Acids; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Protein Isoforms; 0/SREBP cleavage-activating protein; 0/Sterol Regulatory Element Binding Proteins; 57-88-5/Cholesterol

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