Document Detail

Regulation of Cellular Gene Expression and Function by the Human Immunodeficiency Virus Type 1 Tat Protein.
MedLine Citation:
PMID:  11725056     Owner:  NLM     Status:  Publisher    
The human immunodeficiency virus type 1 Tat protein is a potent activator of viral gene expression and replication. Tat can also affect the expression of cellular genes including cytokines, extracellular matrix proteins, enzymes degrading the basement membrane and cell cycle-related proteins, and can regulate cellular functions such as growth, migration and angiogenesis. In addition, under certain circumstances, Tat may have tumorigenic effects. These activities of Tat appear to be mediated by different mechanisms such as the transactivation of cellular gene expression or the interaction of extracellular Tat with the cell membrane through both receptor-mediated and nonreceptor-mediated interactions. Deregulation of cellular gene expression and function by Tat cause abnormalities which may participate in AIDS pathogenesis and in the development of AIDS-associated disorders. Copyright 1995 S. Karger AG, Basel
H.-K. Chang; R.C. Gallo; B. Ensoli
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Publication Detail:
Journal Detail:
Title:  Journal of biomedical science     Volume:  2     ISSN:  1423-0127     ISO Abbreviation:  J. Biomed. Sci.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  2001-Nov-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421567     Medline TA:  J Biomed Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  189-202     Citation Subset:  -    
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA.
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