| Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L). | |
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MedLine Citation:
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PMID: 20673843 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Of eight million oocytes formed in fetal ovaries, only 400 are ovulated and the rest are degraded via apoptosis. Studies in rodents suggest an important role for Bok and Bcl-X(L) in ovarian apoptosis, but their expression patterns and roles in human ovaries are not well known. Protein expression of Bok and Bcl-X(L) as well as the death pathway effectors TNF and caspase-3 were determined in an important collection of samples consisting of human fetal and adult ovaries. A penetrant expression of Bok, Bcl-X(L), TNF and full length and cleaved caspase-3 were characterized in fetal ovaries, with specific patterns in oocytes and pre-granulosa/granulosa cells. Bok and Bcl-X(L) were detected also in adult ovaries. Lentiviral shRNA delivery demonstrated that loss of Bok markedly reduces vulnerability to apoptosis and, conversely, loss of Bcl-X(L) increases apoptosis in human granulosa tumour cell line. The results suggest important roles for Bok and Bcl-X(L) in human ovarian development, follicle maturation and apoptosis. |
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Authors:
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Minna Jääskeläinen; Anni Nieminen; Reeta-Maria Pökkylä; Marjut Kauppinen; Annikki Liakka; Markku Heikinheimo; Tommi E Vaskivuo; Juha Klefström; Juha S Tapanainen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-29 |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 330 ISSN: 1872-8057 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 17-24 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Oulu, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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