Document Detail


Regulation of cell death by transfer RNA.
MedLine Citation:
PMID:  23350625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SIGNIFICANCE: Both transfer RNA (tRNA) and cytochrome c are essential molecules for the survival of cells. tRNA decodes mRNA codons into amino-acid-building blocks in protein in all organisms, whereas cytochrome c functions in the electron transport chain that powers ATP synthesis in mitochondrion-containing eukaryotes. Additionally, in vertebrates, cytochrome c that is released from mitochondria is a potent inducer of apoptosis, activating apoptotic proteins (caspases) in the cytoplasm to dismantle cells. A better understanding of both tRNA and cytochrome c is essential for an insight into the regulation of cell life and death.
RECENT ADVANCES: A recent study showed that the mitochondrion-released cytochrome c can be removed from the cell-death pathway by tRNA molecules. The direct binding of cytochrome c by tRNA provides a mechanism for tRNA to regulate cell death, beyond its role in gene expression.
CRITICAL ISSUES: The nature of the tRNA-cytochrome c binding interaction remains unknown. The questions of how this interaction affects tRNA function, cellular metabolism, and apoptotic sensitivity are unanswered.
FUTURE DIRECTIONS: Investigations into the critical issues raised above will improve the understanding of tRNA in the fundamental processes of cell death and metabolism. Such knowledge will inform therapies in cell death-related diseases.
Authors:
Ya-Ming Hou; Xiaolu Yang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-03-28
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  19     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-19     Completed Date:  2014-02-03     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  583-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Caspases / metabolism
Cytochromes c / metabolism
Electron Transport Chain Complex Proteins / physiology
Enzyme Activation
Genes, Mitochondrial
Humans
Mitochondrial Membranes
Neoplasms / pathology,  therapy
Nucleic Acid Conformation
Permeability
RNA, Transfer / physiology*
Grant Support
ID/Acronym/Agency:
AG042169/AG/NIA NIH HHS; GM060911/GM/NIGMS NIH HHS; GM081601/GM/NIGMS NIH HHS; P30 CA016520/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Electron Transport Chain Complex Proteins; 9007-43-6/Cytochromes c; 9014-25-9/RNA, Transfer; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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