| Regulation of B-cell entry into the cell cycle. | |
| | |
MedLine Citation:
|
PMID: 18759927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
B cells are induced to enter the cell cycle by stimuli including ligation of the B-cell receptor (BCR) complex and Toll-like receptor (TLR) agonists. This review discusses the contribution of several molecules, which act at distinct steps in B-cell activation. The adapter molecule Bam32 (B-lymphocyte adapter of 32 kDa) helps promote BCR-induced cell cycle entry, while the secondary messenger superoxide has the opposite effect. Bam32 and superoxide may fine tune BCR-induced activation by competing for the same limited resources, namely Rac1 and the plasma membrane phospholipid PI(3,4)P(2). The co-receptor CD22 can inhibit BCR-induced proliferation by binding to novel CD22 ligands. Finally, regulators of B-cell survival and death also play roles in B-cell transit through the cell cycle. Caspase 6 negatively regulates CD40- and TLR-dependent G(1) entry, while acting later in the cell cycle to promote S-phase entry. Caspase 6 deficiency predisposes B cells to differentiate rather than proliferate after stimulation. Bim, a pro-apoptotic Bcl-2 family member, exerts a positive regulatory effect on cell cycle entry, which is opposed by Bcl-2. New insights into what regulates B-cell transit through the cell cycle may lead to thoughtful design of highly selective drugs that target pathogenic B cells. |
| | |
Authors:
|
Sabrina Richards; Chie Watanabe; Lorna Santos; Andrew Craxton; Edward A Clark |
Related Documents
:
|
19074847 - A peptide inhibitor derived from p55pik phosphatidylinositol 3-kinase regulatory subuni... 10699467 - Opposing changes in n-acetylglucosaminyltransferase-v and -iii during the cell cycle an... 3875577 - Recruitment of cells in the small intestine into rapid cell cycle by small doses of ext... 6363427 - Bud formation by the yeast saccharomyces cerevisiae is directly dependent on "start". 8217877 - Relationship of hsp27 and oestrogen receptor in hormone sensitive and insensitive cell ... 3322507 - L-homocysteate is a potent neurotoxin on cultured cortical neurons. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Immunological reviews Volume: 224 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-09-01 Completed Date: 2008-11-03 Revised Date: 2011-05-12 |
Medline Journal Info:
|
Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
|
Languages: eng Pagination: 183-200 Citation Subset: IM |
Affiliation:
|
Department of Immunology and Microbiology, University of Washington, Seattle, WA 98195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptor Proteins, Signal Transducing
/
immunology,
metabolism Animals Antigens, CD22 / metabolism Apoptosis Regulatory Proteins / immunology* B-Lymphocytes / cytology*, immunology*, metabolism Cell Cycle / immunology* Cell Proliferation Cell Survival / immunology Humans Lymphocyte Activation / immunology NADPH Oxidase / immunology, metabolism Receptors, Antigen, B-Cell / immunology, metabolism* Signal Transduction / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
AI44250/AI/NIAID NIH HHS; AI52203/AI/NIAID NIH HHS; DE16381/DE/NIDCR NIH HHS; GM37905/GM/NIGMS NIH HHS; R01 DE016381-04/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adaptor Proteins, Signal Transducing; 0/Antigens, CD22; 0/Apoptosis Regulatory Proteins; 0/DAPP1 protein, human; 0/Receptors, Antigen, B-Cell; EC 1.6.3.1/NADPH Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.
Next Document: Regulatory B cells as inhibitors of immune responses and inflammation.