| Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review). | |
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MedLine Citation:
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PMID: 9852253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell death is a common event during B cell development. The demise of developing B cells is a regulated process that serves to select cell populations bearing functional receptors and to remove cells that are no longer needed or potentially autoreactive. Bcl-2 and Bcl-XL, two members of the bcl-2 gene family of programmed cell death regulators with anti-apoptotic activity, are expressed in a highly regulated pattern during B cell maturation. Overexpression of Bcl-2 in developing B cells of transgenic mice, in the presence of T cell dependent costimulatory signals, results in the generation of a modified B cell repertoire and in the production of pathogenic autoantibodies. While disregulation of programmed cell death in B cells may cause autoimmune manifestations in mice, the involvement of such alterations in the pathogenesis of autoimmune diseases in humans merits further investigation. |
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Authors:
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M López-Hoyos; R Carrió; J Merino; R Merino |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of molecular medicine Volume: 1 ISSN: 1107-3756 ISO Abbreviation: Int. J. Mol. Med. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: GREECE |
Other Details:
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Languages: eng Pagination: 475-83 Citation Subset: IM |
Affiliation:
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Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* / genetics Autoimmune Diseases / immunology* B-Lymphocytes / cytology, immunology* Cell Compartmentation Humans Immune Tolerance / immunology Mice Proto-Oncogene Proteins c-bcl-2 / genetics, immunology* bcl-X Protein |
| Chemical | |
Reg. No./Substance:
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0/BCL2L1 protein, human; 0/Bcl2l1 protein, mouse; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-X Protein |
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