Document Detail


Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).
MedLine Citation:
PMID:  9852253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell death is a common event during B cell development. The demise of developing B cells is a regulated process that serves to select cell populations bearing functional receptors and to remove cells that are no longer needed or potentially autoreactive. Bcl-2 and Bcl-XL, two members of the bcl-2 gene family of programmed cell death regulators with anti-apoptotic activity, are expressed in a highly regulated pattern during B cell maturation. Overexpression of Bcl-2 in developing B cells of transgenic mice, in the presence of T cell dependent costimulatory signals, results in the generation of a modified B cell repertoire and in the production of pathogenic autoantibodies. While disregulation of programmed cell death in B cells may cause autoimmune manifestations in mice, the involvement of such alterations in the pathogenesis of autoimmune diseases in humans merits further investigation.
Authors:
M López-Hoyos; R Carrió; J Merino; R Merino
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  1     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  475-83     Citation Subset:  IM    
Affiliation:
Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis* / genetics
Autoimmune Diseases / immunology*
B-Lymphocytes / cytology,  immunology*
Cell Compartmentation
Humans
Immune Tolerance / immunology
Mice
Proto-Oncogene Proteins c-bcl-2 / genetics,  immunology*
bcl-X Protein
Chemical
Reg. No./Substance:
0/BCL2L1 protein, human; 0/Bcl2l1 protein, mouse; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-X Protein

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