| Regulation of autophagy in the heart: "you only live twice". | |
| | |
MedLine Citation:
|
PMID: 20712404 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract Autophagy is a highly orchestrated cellular process by which proteins and organelles are degraded via an elaborate lysosomal pathway to generate free amino acids and sugars for ATP during metabolic stress. At present, the exact role of autophagy in the heart is highly debated but suggested to play a key role in regulating cell turnover in cardiomyopathies and heart failure. The signaling pathways and molecular effectors that govern autophagy are incomplete, as are the mechanisms that determine whether autophagy promotes or prevents cell death. The mitochondrion has been identified as a key organelle centrally involved in regulating autophagy. Certain members of the Bcl-2 gene family, including Beclin-1, Bcl-2 nineteen kilodaltons interacting protein (Bnip3), and Nix/Bnip3L, provoke mitochondrial perturbations leading to permeability transition pore opening, resulting in apoptosis, autophagy, or both. These and other aspects of autophagy processes have been discussed. Antioxid. Redox Signal. 14, 2245-2250. |
| | |
Authors:
|
Yaron Aviv; James Shaw; Hongying Gang; Lorrie A Kirshenbaum |
Related Documents
:
|
7654884 - Review article: manipulation of cell death--the development of novel strategies for the... 8917724 - Transglutaminase induction by various cell death and apoptosis pathways. 18158874 - Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell l... 9665184 - The study of apoptotic cells by flow cytometry. 1605474 - Macrophages and astroglial interactions in repair to brain injury. 9591044 - High-grade malignant non-hodgkin's lymphomas differ from low-grade lymphomas in the ext... |
Publication Detail:
|
Type: Journal Article Date: 2011-01-07 |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 14 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 2245-50 Citation Subset: IM |
Affiliation:
|
1 Department of Pharmacology and Therapeutics, The Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, University of Manitoba , Winnipeg, Manitoba, Canada . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oncosuppressive functions of autophagy.
Next Document: Autophagosome formation and molecular mechanism of autophagy.