Document Detail


Regulating mitosis and meiosis in the male germ line: critical functions for cyclins.
MedLine Citation:
PMID:  20403876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Key components of the cell cycle machinery are the regulatory subunits, the cyclins, and their catalytic partners the cyclin-dependent kinases. Regulating the cell cycle in the male germ line cells represents unique challenges for this machinery given the constant renewal of gametes throughout the reproductive lifespan and the induction of the unique process of meiosis, a highly specialized kind of cell division. With challenges come opportunities to the critical eye, recognizing that understanding these specialized modes of regulation will provide considerable insight into both normal differentiation as well as disease conditions, including infertility and oncogenesis.
Authors:
Debra J Wolgemuth; Shelby S Roberts
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  365     ISSN:  1471-2970     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-09-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1653-62     Citation Subset:  IM    
Affiliation:
Department of Genetics and Development, Columbia University Medical Center, 1150 St Nicholas Avenue, Room 608, New York, NY 10032, USA. djw3@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology
Cyclin-Dependent Kinases / physiology
Cyclins / physiology*
Humans
Male
Meiosis / physiology*
Mitosis / physiology*
Spermatogenesis / physiology
Spermatozoa / cytology*,  physiology
Grant Support
ID/Acronym/Agency:
HD034915/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Cyclins; EC 2.7.11.22/Cyclin-Dependent Kinases
Comments/Corrections

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