Document Detail


Regulating the conversion between rounded and elongated modes of cancer cell movement.
MedLine Citation:
PMID:  18977323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cell metastasis.
Authors:
Daniel R Croft; Michael F Olson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer cell     Volume:  14     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2008-11-18     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-51     Citation Subset:  IM    
Affiliation:
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / metabolism
Cell Movement / physiology*
GTPase-Activating Proteins / metabolism
Gene Expression Regulation, Neoplastic
Guanine Nucleotide Exchange Factors / metabolism
Humans
Melanoma / metabolism,  pathology*,  secondary
Nerve Tissue Proteins / metabolism
Phosphoproteins / metabolism
Signal Transduction*
Wiskott-Aldrich Syndrome Protein Family / metabolism
rac GTP-Binding Proteins / metabolism
rho GTP-Binding Proteins / metabolism
Chemical
Reg. No./Substance:
0/ARHGAP21 protein, human; 0/ARHGAP22 protein, human; 0/Adaptor Proteins, Signal Transducing; 0/DOCK3 protein, human; 0/GTPase-Activating Proteins; 0/Guanine Nucleotide Exchange Factors; 0/NEDD9 protein, human; 0/Nerve Tissue Proteins; 0/Phosphoproteins; 0/WASF2 protein, human; 0/Wiskott-Aldrich Syndrome Protein Family; EC 3.6.5.2/rac GTP-Binding Proteins; EC 3.6.5.2/rho GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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