Document Detail

Regulated ubiquitination of proteins in GPCR-initiated signaling pathways.
MedLine Citation:
PMID:  14723977     Owner:  NLM     Status:  MEDLINE    
The transmission of information through G-protein-coupled receptor (GPCR)-initiated signaling pathways is modulated in several ways. Although phosphorylation of some of the proteins that populate these pathways is a well-known modulatory process, recent studies have shown that signaling proteins can also undergo regulated ubiquitination in response to GPCR activation, with diverse consequences. To date, three GPCRs, some of their associated proteins and certain downstream mediators, notably inositol (1,4,5)-trisphosphate [Ins(1,4,5)P(3)] receptors, have been shown to be ubiquitinated following GPCR activation. Regulated ubiquitination causes proteasomal degradation of Ins(1,4,5)P(3) receptors and appears to control GPCR endocytosis and trafficking. Defining the roles of ubiquitination in GPCR-mediated signaling is an important task because novel drugs that perturb the ubiquitin-proteasome pathway are now being approved as therapeutic agents.
Richard J H Wojcikiewicz
Related Documents :
20546777 - Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists.
21378277 - Alantolactone inhibits cell proliferation by interrupting the interaction between cript...
16093557 - Quantitative cell-based high-content screening for vasopressin receptor agonists using ...
18674637 - The vascular s1p gradient-cellular sources and biological significance.
24890717 - Characterization of conventional and atypical receptors for the chemokine ccl2 on mouse...
1334007 - Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen rec...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  25     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-15     Completed Date:  2004-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Department of Pharmacology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210-2339, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Receptors, G-Protein-Coupled / drug effects,  physiology*
Signal Transduction / physiology*
Ubiquitin / pharmacology,  physiology*
Reg. No./Substance:
0/Receptors, G-Protein-Coupled; 0/Ubiquitin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  From the street to the brain: neurobiology of the recreational drug gamma-hydroxybutyric acid.
Next Document:  Current pharmacological treatments for nicotine dependence.