Document Detail


Regulated tissue fluidity steers zebrafish body elongation.
MedLine Citation:
PMID:  23293289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tailbud is the posterior leading edge of the growing vertebrate embryo and consists of motile progenitors of the axial skeleton, musculature and spinal cord. We measure the 3D cell flow field of the zebrafish tailbud and identify changes in tissue fluidity revealed by reductions in the coherence of cell motion without alteration of cell velocities. We find a directed posterior flow wherein the polarization between individual cell motion is high, reflecting ordered collective migration. At the posterior tip of the tailbud, this flow makes sharp bilateral turns facilitated by extensive cell mixing due to increased directional variability of individual cell motions. Inhibition of Wnt or Fgf signaling or cadherin 2 function reduces the coherence of the flow but has different consequences for trunk and tail extension. Modeling and additional data analyses suggest that the balance between the coherence and rate of cell flow determines whether body elongation is linear or whether congestion forms within the flow and the body axis becomes contorted.
Authors:
Andrew K Lawton; Amitabha Nandi; Michael J Stulberg; Nicolas Dray; Michael W Sneddon; William Pontius; Thierry Emonet; Scott A Holley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Biomechanical Phenomena
Body Patterning*
Cadherins / genetics,  metabolism
Cell Adhesion
Cell Count
Cell Movement*
Cell Polarity
Computer Simulation
Embryo, Nonmammalian / cytology,  metabolism
Embryonic Development
Fibroblast Growth Factors / genetics,  metabolism
Gene Expression Regulation, Developmental*
Models, Biological
Tail / embryology,  metabolism
Time Factors
Wnt Signaling Pathway
Zebrafish / embryology*,  genetics,  metabolism
Zebrafish Proteins / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
R01 HD045738/HD/NICHD NIH HHS; T32 GM007499/GM/NIGMS NIH HHS; T32 HD07180-29/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Cadherins; 0/N-cadherin, zebrafish; 0/Zebrafish Proteins; 62031-54-3/Fibroblast Growth Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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