Document Detail


Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells.
MedLine Citation:
PMID:  20219824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kidney is a major site of systemic oxygen sensing, regulating blood erythrocyte and hence oxygen content by hypoxia-inducible erythropoietin (Epo) expression. A constant ratio between blood perfusion and oxygen consumption, a stable corticomedullary oxygen gradient, and a relatively low tissue Po(2) are the prerequisites for the function of renal Epo-producing and oxygen-sensing (REPOS) cells, which are located in the juxtamedullary cortex. In kidney disease, renal oxygen consumption is decreased, leading to an increase in Po(2), dysfunction of REPOS cells, and anemia. The molecular principles of cellular oxygen sensing have been elucidated in the last few years, and genetically altered mouse models as well as hereditary diseases causing erythrocytosis have clarified the oxygen-signaling cascade leading to increased Epo expression in REPOS cells. However, the consequences of a number of recently discovered factors for the regulation of oxygen signaling in REPOS cells are unclear, asking for novel cell culture models which might be hampered by the putative neuron-like nature of this enigmatic cell type.
Authors:
Roland H Wenger; David Hoogewijs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-10
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  298     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-06-14     Revised Date:  2011-04-28    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F1287-96     Citation Subset:  IM    
Affiliation:
Institute of Physiology and Zürich Center for Integrative Human Physiology ZIHP, University of Zürich, Zürich, Switzerland. roland.wenger@access.uzh.ch
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MeSH Terms
Descriptor/Qualifier:
Anemia / drug therapy,  etiology*,  genetics,  metabolism,  pathology
Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism
Erythropoietin / blood,  genetics,  metabolism*,  therapeutic use
Feedback, Physiological
Gene Expression Regulation
Hematinics / therapeutic use
Humans
Hydroxylation
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Kidney / blood supply,  metabolism*,  pathology
Kidney Diseases / complications,  drug therapy,  genetics,  metabolism*,  pathology
Oxygen / blood,  metabolism*
Oxygen Consumption
Polycythemia / metabolism,  pathology
Procollagen-Proline Dioxygenase / metabolism
Renal Circulation
Signal Transduction
Von Hippel-Lindau Tumor Suppressor Protein / metabolism
Chemical
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Hematinics; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/endothelial PAS domain-containing protein 1; 11096-26-7/Erythropoietin; 7782-44-7/Oxygen; EC 1.14.11.2/EGLN1 protein, human; EC 1.14.11.2/Procollagen-Proline Dioxygenase; EC 6.3.2.19/VHL protein, human; EC 6.3.2.19/Von Hippel-Lindau Tumor Suppressor Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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