| Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells. | |
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MedLine Citation:
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PMID: 20219824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kidney is a major site of systemic oxygen sensing, regulating blood erythrocyte and hence oxygen content by hypoxia-inducible erythropoietin (Epo) expression. A constant ratio between blood perfusion and oxygen consumption, a stable corticomedullary oxygen gradient, and a relatively low tissue Po(2) are the prerequisites for the function of renal Epo-producing and oxygen-sensing (REPOS) cells, which are located in the juxtamedullary cortex. In kidney disease, renal oxygen consumption is decreased, leading to an increase in Po(2), dysfunction of REPOS cells, and anemia. The molecular principles of cellular oxygen sensing have been elucidated in the last few years, and genetically altered mouse models as well as hereditary diseases causing erythrocytosis have clarified the oxygen-signaling cascade leading to increased Epo expression in REPOS cells. However, the consequences of a number of recently discovered factors for the regulation of oxygen signaling in REPOS cells are unclear, asking for novel cell culture models which might be hampered by the putative neuron-like nature of this enigmatic cell type. |
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Authors:
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Roland H Wenger; David Hoogewijs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-03-10 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 298 ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-06-14 Revised Date: 2011-04-28 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F1287-96 Citation Subset: IM |
Affiliation:
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Institute of Physiology and Zürich Center for Integrative Human Physiology ZIHP, University of Zürich, Zürich, Switzerland. roland.wenger@access.uzh.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
/
drug therapy,
etiology*,
genetics,
metabolism,
pathology Animals Basic Helix-Loop-Helix Transcription Factors / metabolism Erythropoietin / blood, genetics, metabolism*, therapeutic use Feedback, Physiological Gene Expression Regulation Hematinics / therapeutic use Humans Hydroxylation Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Kidney / blood supply, metabolism*, pathology Kidney Diseases / complications, drug therapy, genetics, metabolism*, pathology Oxygen / blood, metabolism* Oxygen Consumption Polycythemia / metabolism, pathology Procollagen-Proline Dioxygenase / metabolism Renal Circulation Signal Transduction Von Hippel-Lindau Tumor Suppressor Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors; 0/Hematinics; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/endothelial PAS domain-containing protein 1; 11096-26-7/Erythropoietin; 7782-44-7/Oxygen; EC 1.14.11.2/EGLN1 protein, human; EC 1.14.11.2/Procollagen-Proline Dioxygenase; EC 6.3.2.19/VHL protein, human; EC 6.3.2.19/Von Hippel-Lindau Tumor Suppressor Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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