Document Detail

Regulated Intramembrane Cleavage of the EGF Receptor(*).
MedLine Citation:
PMID:  22531034     Owner:  NLM     Status:  Publisher    
Following the addition of EGF or ionomycin to A431 cells, protease activity mediates the cleavage of the EGF receptor producing a 60 kDa fragment that includes the intracellular domain (ICD). This fragment is located in both membrane and nuclear fractions. Based on sensitivity to chemical inhibitors and overexpression of cDNAs, the rhomboid intramembrane proteases, not γ-secretase proteases, are identified as responsible for the cleavage event. Agonist-initiated cleavage occurs slowly over 3-24 hrs. Inhibition of calpain protease activity significantly increased the detectable level of ICD fragment.
Hong-Jun Liao; Graham Carpenter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-24
Journal Detail:
Title:  Traffic (Copenhagen, Denmark)     Volume:  -     ISSN:  1600-0854     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939340     Medline TA:  Traffic     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
The Department of Biochemistry, Vanderbilt University School of Medicine Nashville, TN 37232-0146.
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