| Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. | |
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MedLine Citation:
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PMID: 20307585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic stress impairs cognitive function and hippocampal neurogenesis. This impairment is attributed to increases in oxidative stress, which result in the accumulation of lipid peroxide. On the other hand, voluntary exercise enhances cognitive function, hippocampal neurogenesis, and antioxidant capacity in normal animals. However, the effects of voluntary exercise on cognitive function, neurogenesis, and antioxidants in stressed mice are unclear. This study was designed to investigate whether voluntary exercise cures stress-induced impairment of cognitive function accompanied by improvement of hippocampal neurogenesis and increases in antioxidant capacity. Stressed mice were exposed to chronic restraint stress (CRS), which consisted of 12h immobilization daily and feeding in a small cage, for 8 weeks. Exercised mice were allowed free access to a running wheel during their exposure to CRS. At the 6th week, cognitive function was examined using the Morris water maze (MWM) test. Daily voluntary exercise restored stress-induced impairment of cognitive function and the hippocampal cell proliferation of newborn cells but not cell survival. Voluntary exercise increased insulin-like growth factor 1 (IGF-1) protein and mRNA expression in the cerebral cortex and liver, respectively. In addition, CRS resulted in a significant increase in the number of 4-hydrosynonenal (4-HNE)-positive cells in the hippocampal dentate gyrus; whereas, voluntary exercise inhibited it and enhanced glutathione s-transferases (GST) activity in the brain. These findings suggest that voluntary exercise attenuated the stress-induced impairment of cognitive function accompanied by improvement of cell proliferation in the dentate gyrus. This exercise-induced improvement was attributed to exercise-induced enhancement of IGF-1 protein and GST activity in the brain. |
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Authors:
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Sanae Nakajima; Ikuroh Ohsawa; Shigeo Ohta; Makoto Ohno; Toshio Mikami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-20 |
Journal Detail:
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Title: Behavioural brain research Volume: 211 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 178-84 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa 211-8533, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Cell Proliferation Cerebral Cortex / cytology, metabolism Cognition / physiology Dentate Gyrus / cytology*, physiology Glutathione Transferase / metabolism* Hippocampus / cytology, physiology* Insulin-Like Growth Factor I / genetics, metabolism* Liver / metabolism Male Maze Learning / physiology* Mice Mice, Inbred C57BL Neurogenesis / physiology Physical Conditioning, Animal / physiology* RNA, Messenger / analysis Random Allocation Stress, Psychological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 67763-96-6/Insulin-Like Growth Factor I; EC 2.5.1.18/Glutathione Transferase |
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